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1

Enantioselective Total Synthesis of (−)-Taxol

Kusama, Hiroyuki, Hara, Ryoma, Kawahara, Shigeru, Nishimori, Toshiyuki, Kashima, Hajime, Nakamura, Nobuhito, Morihira, Koichiro, Kuwajima, Isao

Journal:

Journal of the American Chemical Society

Year:

2000

Language:

english

File:

PDF, 688 KB

english, 2000

2

Total Synthesis of Ingenol

Tanino, Keiji, Onuki, Kei, Asano, Kohei, Miyashita, Masaaki, Nakamura, Tsuyoshi, Takahashi, Yoshinori, Kuwajima, Isao

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 101 KB

english, 2003

3

Fluoride Catalyzed Addition of Silylacetylenes to Carbonyl Compounds

Prof. Dr. Eiichi Nakamura, Isao Kuwajima

Journal:

Angewandte Chemie International Edition

Year:

1976

Language:

english

File:

PDF, 228 KB

english, 1976

4

Reactions of phenyl isocyanate with vinyl ethers

Teruaki Mukaiyama, Ryuichiro Yoda, Isao Kuwajima

Journal:

Tetrahedron Letters

Year:

1966

Language:

english

File:

PDF, 91 KB

english, 1966

5

Generation of the enolate of succinic anhydride in the presence of carbonyl compounds. A facile preparative method of β-methoxycarbonyl γ-substituted γ-butyrolactones

Naoki Minami, Isao Kuwajima

Journal:

Tetrahedron Letters

Year:

1977

Language:

english

File:

PDF, 126 KB

english, 1977

6

Trichlorotitanium and alkoxytitanium homoenolates. Preparation, characterization, and utilization for organic synthesis

Nakamura, Eiichi., Oshino, Hiroji., Kuwajima, Isao.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 1.24 MB

english, 1986

7

Enantioselective Total Synthesis of Taxol

Morihira, Koichiro, Hara, Ryoma, Kawahara, Shigeru, Nishimori, Toshiyuki, Nakamura, Nobuhito, Kusama, Hiroyuki, Kuwajima, Isao

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 59 KB

english, 1998

8

Fluorid-katalysierte Addition von Silylacetylenen an Carbonylverbindungen

Eiichi Nakamura, Prof. Dr. Isao Kuwajima

Journal:

Angewandte Chemie

Year:

1976

Language:

german

File:

PDF, 124 KB

german, 1976

9

ChemInform Abstract: Synthesis and Evaluation of Artificial Taxoids with Antitumor and Multi-Drug Resistance Reversing Activities.

Koichiro Morihira, Toshiyuki Nishimori, Hiroyuki Kusama, Yoshiaki Horiguchi, Isao Kuwajima, Takashi Tsuruo

Journal:

Year:

1999

File:

PDF, 34 KB

1999

10

ChemInform Abstract: Synthesis of C-Ring Aromatic Taxoids and Evaluation of Their Multi-Drug Resistance Reversing Activity.

Koichiro Morihari, Toshiyuki Nishimori, Hiroyuki Kusama, Yoshiaki Horiguchi, Isao Kuwajima, Takashi Tsuruo

Journal:

Year:

1999

File:

PDF, 33 KB

1999

11

ChemInform Abstract: Enantioselective Total Synthesis of Taxol.

Koichiro Morihira, Ryoma Hara, Shigeru Kawahara, Toshiyuki Nishimori, Nobuhito Nakamura, Hiroyuki Kusama, Isao Kuwajima

Journal:

Year:

1999

File:

PDF, 24 KB

1999

12

ChemInform Abstract: Enantioselective Total Synthesis of (+)-Taxusin

Ryoma Hara, Takashi Furukawa, Hajime Kashima, Hiroyuki Kusama, Yoshiaki Horiguchi, Isao Kuwajima

Journal:

Year:

1999

File:

PDF, 24 KB

1999

13

ChemInform Abstract: Total Synthesis of (-)-Coriolin.

Hajime Mizuno, Kei Domon, Keiichi Masuya, Keiji Tanino, Isao Kuwajima

Journal:

Year:

1999

File:

PDF, 25 KB

1999

14

ChemInform Abstract: A New Method for the Synthesis of Medium- and Large-Sized Carbocycles.

Keiichi Masuya, Keiji Tanino, Isao Kuwajima

Journal:

Year:

1999

File:

PDF, 34 KB

1999

15

ChemInform Abstract: A Convenient Method for the Synthesis of Δ1,6-Bicyclo[4.n.0]alken-2-ones.

Norihiko Watanabe, Keiji Tanino, Isao Kuwajima

Journal:

Year:

2000

File:

PDF, 36 KB

2000

16

ChemInform Abstract: Enantioselective Total Synthesis of (-)-Taxol.

Hiroyuki Kusama, Ryoma Hara, Shigeru Kawahara, Toshiyuki Nishimori, Hajime Kashima, Nobuhito Nakamura, Koichiro Morihira, Isao Kuwajima

Journal:

Year:

2000

File:

PDF, 23 KB

2000

17

ChemInform Abstract: Enantioselective Total Synthesis of Taxusin and Taxol

Isao Kuwajima, Hiroyuki Kusama

Journal:

Year:

2000

File:

PDF, 24 KB

2000

18

ChemInform Abstract: A Novel [5 + 2] Cycloaddition Reaction Using a Dicobalt Acetylene Complex.

Keiji Tanino, Tadashi Shimizu, Motoki Miyama, Isao Kuwajima

Journal:

Year:

2000

Language:

english

File:

PDF, 33 KB

english, 2000

19

ChemInform Abstract: An Intramolecular Hetero Diels—Alder Reaction of α-(Alkynylsiloxy)aldimine Derivatives.

Tadashi Shimizu, Keiji Tanino, Isao Kuwajima

Journal:

Year:

2000

File:

PDF, 36 KB

2000

20

ChemInform Abstract: Synthetic Studies on Taxoids: Enantioselective Total Synthesis of (+)-Taxusin and (-)-Taxol

Isao Kuwajima, Hiroyuki Kusama

Journal:

Year:

2000

File:

PDF, 24 KB

2000

21

Absolute Configuration of Nafuredin, a New Specific NADH-Fumarate Reductase Inhibitor.

Daisuke Takano, Tohru Nagamitsu, Hideaki Ui, Kazuro Shiomi, Yuuichi Yamaguchi, Rokuro Masuma, Isao Kuwajima, Satoshi Omura

Journal:

Year:

2001

File:

PDF, 27 KB

2001

22

ChemInform Abstract: Total Synthesis of Nafuredin, a Selective NADH-Fumarate Reductase Inhibitor.

Daisuke Takano, Tohru Nagamitsu, Hideaki Ui, Kazuro Shiomi, Yuuichi Yamaguchi, Rokuro Masuma, Isao Kuwajima, Satoshi Omura

Journal:

Year:

2001

File:

PDF, 29 KB

2001

23

ChemInform Abstract: Total Synthesis of Pinellic Acid, a Potent Oral Adjuvant for Nasal Influenza Vaccine. Determination of the Relative and Absolute Configuration.

Toshiaki Sunazuka, Tatsuya Shirahata, Kimiari Yoshida, Daisuke Yamamoto, Yoshihiro Harigaya, Takayuki Nagai, Hiroaki Kiyohara, Haruki Yamada, Isao Kuwajima, Satoshi Omura

Journal:

Year:

2002

File:

PDF, 27 KB

2002

24

ChemInform Abstract: The First Total Synthesis of (.+-.)-Arisugacin A, a Potent, Orally Bioavailable Inhibitor of Acetylcholinesterase.

Toshiaki Sunazuka, Masaki Handa, Kenichiro Nagai, Tatsuya Shirahata, Yoshihiro Harigaya, Kazuhiko Otoguro, Isao Kuwajima, Satoshi Omura

Journal:

Year:

2002

File:

PDF, 31 KB

2002

25

ChemInform Abstract: Short Total Synthesis of (+)-Madindolines A and B.

Tomoyasu Hirose, Toshiaki Sunazuka, Tatsuya Shirahata, Daisuke Yamamoto, Yoshihiro Harigaya, Isao Kuwajima, Satoshi Omura

Journal:

Year:

2002

File:

PDF, 29 KB

2002

26

Total Synthesis of Ingenol (I).

Keiji Tanino, Kei Onuki, Kohei Asano, Masaaki Miyashita, Tsuyoshi Nakamura, Yoshinori Takahashi, Isao Kuwajima

Journal:

Year:

2003

File:

PDF, 63 KB

2003

27

Total Synthesis and Adjuvant Activity of All Stereoisomers of Pinellic Acid.

Tatsuya Shirahata, Toshiaki Sunazuka, Kiminari Yoshida, Daisuke Yamamoto, Yoshihiko Harigaya, Takayuki Nagai, Hiroaki Kiyohara, Haruki Yamada, Isao Kuwajima, Satoshi Omura

Journal:

Year:

2003

File:

PDF, 72 KB

2003

28

Total Synthesis of (-)-Borrelidin (I).

Tohru Nagamitsu, Daisuke Takano, Takeo Fukuda, Kazuhiko Otoguro, Isao Kuwajima, Yoshihiro Harigaya, Satoshi Omura

Journal:

Year:

2004

File:

PDF, 14 KB

2004

29

First Total Synthesis of the Antitumor Compound (-)-Kazusamycin A and Absolute Structure Determination.

Noriyoshi Arai, Noriko Chikaraishi, Satoshi Omura, Isao Kuwajima

Journal:

Year:

2004

File:

PDF, 10 KB

2004

30

Absolute Stereochemistries and Total Synthesis of (+)-Arisugacins A and B, Potent, Orally Bioactive and Selective Inhibitors of Acetylcholinesterase.

Toshiaki Sunazuka, Masaki Handa, Kenichiro Nagai, Tatsuya Shirahata, Yoshihiro Harigaya, Kazuhiko Otoguro, Isao Kuwajima, Satoshi Omura

Journal:

Year:

2004

File:

PDF, 11 KB

2004

31

Total Synthesis of (-)-Physovenine (I) from (-)-3a-Hydroxyfuroindoline (II).

Toshiaki Sunazuka, Kiminari Yoshida, Naoto Kojima, Tatsuya Shirahata, Tomoyasu Hirose, Masaki Handa, Daisuke Yamamoto, Yoshihiro Harigaya, Isao Kuwajima, Satoshi Omura

Journal:

Year:

2005

File:

PDF, 11 KB

2005

32

A Concise Stereoselective Route to the Indoline Spiroaminal Framework of Neoxaline and Oxaline.

Toshiaki Sunazuka, Tatsuya Shirahata, Satoshi Tsuchiya, Tomoyasu Hirose, Ryuma Mori, Yoshihiro Harigaya, Isao Kuwajima, Satoshi Omura

Journal:

Year:

2005

File:

PDF, 12 KB

2005

33

Determination of the Absolute Stereochemistry and Asymmetric Total Synthesis of Madindolines A (I) and B (II): A Practical Improvement to a Second-Generation Approach from the First-Generation.

Tomoyasu Hirose, Toshiaki Sunazuka, Daisuke Yamamoto, Naoto Kojima, Tatsuya Shirahata, Yoshihiro Harigaya, Isao Kuwajima, Satoshi Omura

Journal:

Year:

2005

File:

PDF, 12 KB

2005

34

Studies Toward the Total Synthesis of GKK1032A2 (I), a Structurally Unique Antitumor Compound: Stereoselective Construction of the Tricarbocyclic System.

Noriyoshi Arai, Hideaki Ui, Satoshi Omura, Isao Kuwajima

Journal:

Year:

2005

File:

PDF, 12 KB

2005

35

A Practical Synthesis of (-)-Kazusamycin A.

Shengfeng Zhou, Huaxiang Chen, Wensheng Liao, Shu-Hui Chen, Ge Li, Ryoichi Ando, Isao Kuwajima

Journal:

Year:

2006

File:

PDF, 11 KB

2006

36

Synthetic organic reactions by means of reactive nucleophiles generated through rearrangement of a silyl group

Journal:

Journal of Organometallic Chemistry

Year:

1985

Language:

english

File:

PDF, 753 KB

english, 1985

37

Chlorosilane-accelerated conjugate addition of catalytic and stoichiometric organocopper reagents

Satoshi Matsuzawa, Yoshiaki Horiguchi, Eiichi Nakamura, Isao Kuwajima

Journal:

Year:

1989

Language:

english

File:

PDF, 1006 KB

english, 1989

38

A convenient method for the preparation of β-hydroxy esters

Isao Kuwajima, Naoki Minami, Toshio Sato

Journal:

Tetrahedron Letters

Year:

1976

Language:

english

File:

PDF, 221 KB

english, 1976

39

Oxidation of olefins with diphenyl diselenide-bromine-hexabutyldistannoxane. A one-step preparation of α-phenylseleno carbonyl compounds from olefins

Isao Kuwajima, Makoto Shimizu

Journal:

Tetrahedron Letters

Year:

1978

Language:

english

File:

PDF, 216 KB

english, 1978

40

Highly stereoselective chelation controlled ene-reaction of 2-(alkylthio)allyl silyl ethers

Takashi Nakamura, Keiji Tanino, Isao Kuwajima

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 212 KB

english, 1993

41

3-(Alkylthio)-1,2-bis(siloxy)-3-butenes as efficient chirality transferred building blocks

Keiichi Masuya, Keiji Tanino, Isao Kuwajima

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 172 KB

english, 1994

42

An enantioselective synthesis of the A-Ring fragment of taxol

Takashi Nakamura, Nobuaki Waizumi, Yoshiaki Horiguchi, Isao Kuwajima

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 167 KB

english, 1994

43

Methylenecyclopentane annulation via formal [3 + 2] cycloaddition reaction

Yoshinori Takahashi, Keiji Tanino, Isao Kuwajima

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 173 KB

english, 1996

44

Design, synthesis, and evaluation of novel kazusamycin A derivatives as potent antitumor agents

Ryoichi Ando, Yusaku Amano, Hideo Nakamura, Noriyoshi Arai, Isao Kuwajima

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 129 KB

english, 2006

45

Determination of the absolute stereochemistry and asymmetric total synthesis of madindolines A and B: a practical improvement to a second-generation approach from the first-generation

Tomoyasu Hirose, Toshiaki Sunazuka, Daisuke Yamamoto, Naoto Kojima, Tatsuya Shirahata, Yoshihiro Harigaya, Isao Kuwajima, Satoshi Ōmura

Journal:

Year:

2005

Language:

english

File:

PDF, 1.25 MB

english, 2005

46

Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acids

Tatsuya Shirahata, Toshiaki Sunazuka, Kiminari Yoshida, Daisuke Yamamoto, Yoshihiro Harigaya, Isao Kuwajima, Takayuki Nagai, Hiroaki Kiyohara, Haruki Yamada, Satoshi Ōmura

Journal:

Year:

2006

Language:

english

File:

PDF, 702 KB

english, 2006

47

Enantioselective preparation of asymmetrically protected 2-propanoyl-1,3-propanediol derivatives: toward the total synthesis of Kazusamycin A

Noriyoshi Arai, Noriko Chikaraishi, Mitsuhiro Ikawa, Satoshi Ōmura, Isao Kuwajima

Journal:

Tetrahedron: Asymmetry

Year:

2004

Language:

english

File:

PDF, 326 KB

english, 2004

48

Total synthesis of (−)-physovenine from (−)-3a-hydroxyfuroindoline

Toshiaki Sunazuka, Kiminari Yoshida, Naoto Kojima, Tatsuya Shirahata, Tomoyasu Hirose, Masaki Handa, Daisuke Yamamoto, Yoshihiro Harigaya, Isao Kuwajima, Satoshi Ōmura

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 111 KB

english, 2005

49

A practical synthesis of (−)-kazusamycin A (revised)

Shengfeng Zhou, Huaxiang Chen, Wensheng Liao, Shu-Hui Chen, Ge Li, Ryoichi Ando, Isao Kuwajima

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

50

Preparation of α, β-unsaturated acyltrimethylsilanes

Naoki Minami, Toru Abe, Isao Kuwajima

Journal:

Journal of Organometallic Chemistry

Year:

1978

Language:

english

File:

PDF, 192 KB

english, 1978